CD Skripsi

Sintesis Dan Uji Toksisitas Dua Analog Senyawa Kalkon Turunan 2’-Metoksiasetofenon

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Chalcone is the one of secondary metabolites which included into the class of flavonoids that are known to have biological activities. Chalcone can be used as an intermediate for synthesizing heterocyclic compounds, such as flavones, flavanols, flavanones and others that also have biological activities. Two chalcone analogues i.e. (E)-3-(2,5-dimetoksifenil)-1-(2’-metoksifenil)prop-2-en-1-on (CN1) dan (E)-1-(2’-metoksifenil)-3-(3,4,5-trimetoksifenil)prop-2-en-1-on (CN2) were synthesized by using KOH as a catalyst with Claisen-Schmidt condensation under microwave irradiation. Compound CN1 obtained in the form of brownish-yellow caramel with yield 41,23% and compound CN2 obtained in the form of yellow solid with yield 61,31%. The compounds structure were identified based on the interpretation of spectroscopic data included UV, IR, 1H-NMR and MS. Toxicity of these chalcones were determined using the Brine Shrimp Lethality Test (BSLT) method againts larvae of Artemia salina Leach. Our finding showed that LC50 value of compound CN1 and CN2 were 11,72 μg/mL and 12,68 μg/mL respectively. The result showed that compound CN1 and CN2 had potential as anticancer with their LC50 were less than 200 mg/mL.
Keywords: Brine Shrimp Lethality Test (BSLT), chalcones, toxicity

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

03 02. 115 (0025)

Penerbit

Pekanbaru : Universitas Riau - FMIPA - Kimia., 2015

Deskripsi Fisik

xii,36 hlm.: ill.: 29 cm

Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

03 02. 115 (0025)

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

Dewa

Versi lain/terkait

Lampiran Berkas

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