CD Skripsi

Pembuatan Microcarrier Berbahan Baku Hidroksiapatit Menggunakan Metode Protein Foaming-Starch Consolidation

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Macroporoous microcarrier is one of tissue engineering technology that consist of support matrix and can be used as a cell culture medium in bioreactor. Protein foaming-starch consolidation method is choosed for manufacturing porous hydroxyapatite with egg yolk as a pore-forming agent. The purpose of this study was to determined the effect of yolk addition, sintering temperature, and drying temperature on the physical, chemical and mechanical properties of porous hydroxyapatite made by protein foaming-starch consolidation method. This research was begun with mixing the hydroxyapatite powder, starch, Darvan 821A and yolk. S;urry was stirred mechanically in speed of 150 rpm for 3 hours. Slurry was poured in mold and heated in oven with the temperature of 180oC for an hour. Then sample was released from mold and burnt at 600oC ended by sintering at 1250oC for an hour. The experimental resulted porous hydroxyapatite with average pore size differs from 13.7-17.9 μm, degree of porosity 59.3-63.6 % and compressive strength 5.17-8.2 MPa. Significance level between variables can be seen from pvalue < 0.05 and lack of fit > 0.05 which show that model was corresponding toward the result. R2 obtained were Y1 = 0.9957%, Y2 = 0.9933% and Y3 = 0.98%. The most effecting factor significantly towards all the responses was hydroxyapatite addition that followed by mixing rate and temperature rising rate of sintering. Optimum condition hydroxyapatite addition of 22 gr, mixing rate of 150 rpm and temperature rising rate of sintering of 2.8oC/menit with the optimum value of response for pore size by 17.665 μm, porosity by 63.475% and compressive strength 5.17 MPa.
Keywords: hydroxyapatite, microcarrier, protein foaming-starch consolidation, response surface methodology

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

07 02. 117 (0086)

Penerbit

Pekanbaru : Universitas Riau – Fakultas Teknik – Teknik Kimia., 2017

Deskripsi Fisik

xiv, 51 hlm.; ill.; 29 cm

Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

07 02. 117 (0086)

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

DAUS

Versi lain/terkait

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