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Gambaran Histopatologi Mukosa Nasofaring Mencit Putih (Mus musculus L.) Jantan Setelah Dipaparkan Asap Pembakaran Hutan
Wildfire is a fire that occurred in the forest and can occur intentionally or not. in Hunan (China) has occurred 55 spots of wildfire From July 1 to August 4 2013. According to the data by national aeronautics and space administration (NASA) on platform fires global forest watch fires (GFW fires), half of the fire hotspots warning in Riau occurred in protected areas or forest moratorium area. As many as 38% of wildfires occurred at the location of peat that has carbon stocks resulting smoke that are harmful to body. Wildfire smoke contains benzo-a pyrene, carbon monoxide (CO), sulfur dioxide (SO2), particulate matter (PM),etc. The content of wildfire smoke is focused on benzo-a pyrene or commonly called polycyclic aromatic hydrocarbons is unhealthy content that are carcinogenic pollutants causing lung carcinoma, oral carcinoma, and nasopharyngeal carcinoma (NPC). The goal of this research is to determine a clear picture of male mice nasopharyngeal histopathology after smoke burning exposure for 7 days with a duration of 10, 15, and 20 minutes/day. This research use 20 white male mice aged 2-3 months which were divided into 4 groups. Control group (K) was not given the exposure. The group p1, p2, and p3 were exposed to smoke with a duration of each 10, 15, 20 minutes/day for 7 days. In this study, the changes that were assessed by using a microscope on nasopharyngeal mucosa are hyperplasia and dysplasia with mild/moderate/severe. The results in this study are in group K:0 (normal), the group p1:1(hyperplasia), and p2 group:3 (moderate dysplasia) and p3 group:4 (severe dysplasia). The conclusion of this research is there are any changes found on white male mice nasopharyngeal histopathology after smoke burning exposure.
Keywords: wildfire smoke, mice, histopathology, hyperplasia/dysplasia cells, nasopharyngeal.
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