Image of SINTESIS DAN UJI TOKSISITAS TURUNAN SENYAWA PIRAZOL 3–(2–KLOROFENIL)–5–(3,4–DIMETOKSIFENIL)–1–FENIL–1H–PIRAZOL
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SINTESIS DAN UJI TOKSISITAS TURUNAN SENYAWA PIRAZOL 3–(2–KLOROFENIL)–5–(3,4–DIMETOKSIFENIL)–1–FENIL–1H–PIRAZOL

Pyrazole compound is a five-ring heterocyclic compound with three carbon atoms and two nitrogen atoms, which are included in one of the secondary metabolites of the alkaloid group. Pyrazole compound to have various biological activities, such as anticancer, antitumor and antioxidants. Pyrazole derivatives, 3–(2–chlorophenyl)–5–(3,4–dimethoxyphenyl)–1–phenyl–1H–pyrazole (TFP-2Cl-3,4OMe) was synthesized through the oxidative aromatic reaction of pyrazoline compound 3–(2–chlorophenyl)–5–(3,4–dimethoxyphenyl)–1–phenyl–4,5–dihidro–1H–pyrazole (PF-2Cl-3,4OMe) with glacial acetic acid using a heating method with reflux. The yield obtained from the synthesis of this compound was 24.55%. The structure of the compound was identified by UV and FTIR spectroscopy. Aanalyzed toxicity test determined by the Brine Shrimp Lethality Test (BSLT) method. LC50 values of pyrazole compound was 3,640 µg / mL. So, it can be concluded that the pyrazole compound is toxic.
Keywords :pyrazoline, pyrazole, reflux

Ketersediaan
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Perpustakaan Universitas Riau 03 02. 119 (0052)
03 02. 119 (0052)
Tersedia
Informasi Detail
Judul Seri
-
No. Panggil
03 02. 119 (0052)
Penerbit
Pekanbaru : Universitas Riau – FMIPA – Kimia.,
Deskripsi Fisik
xiv, 48 hlm.: ill.: 29 cm
Bahasa
Indonesia
ISBN/ISSN
-
Klasifikasi
03 02. 119 (0052)
Tipe Isi
-
Tipe Media
-
Tipe Pembawa
-
Edisi
-
Subjek
KIMIA
Info Detail Spesifik
-
Pernyataan Tanggungjawab
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Tidak tersedia versi lain

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