CD Skripsi

Sintesis Dan Uji Toksisitas Senyawa Kalkon (E)-1-(4-(4-Bromobutoksi)Fenil)-3- (2- Metoksifenil)Prop-2-En-1-On

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ABSTRACT
Chalcone is one of the secondary metabolite compound of flavonoid group that has C6-C3-C6 as a molecule formula which is known to have diverse biological activities such as antibacterial, antimalarial, antituberkular, anticancer and antioxidant. Chalcone analogue (E)-1-(4-(4-bromobutoxy)phenyl)-3-(2 metoxyphenyl)prop-2-en-1-one (DO1-Br) was synthesized via nucleophilic substitution reaction of chalcone (E)-1-(4-hydroxyphenyl)-3-phenylprop-2-en-1-one (DO1) dan 1,4-dibromobutane using K2CO3 as catalyst by reflux method. Chalcone was prepared by condensing 4′-hidroxyacetophenone and 2-metoxybenzaldehide using KOH as catalyst. DO1 compound was synthesized via microwave irradiation at 180 W. Purity of the compounds were checked on TLC plates, melting point and HPLC analysis. The structure of synthesized compounds were confirmed by UV, FTIR, NMR and HRMS spectrocopy studies. The toxicity of chalcone was evaluated by Brine Shrimp Lethality Test (BSLT) method. Chalcone DO1 showed high toxicity with LC50 = 49,54 µg/mL, while chalcone DO1-Br considered non-toxic as LC50 = 127,644 x 103 µg/mL.
Keywords: BSLT, chalcone, reflux, toxicity

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

03 02. 117 (0087)

Penerbit

Pekanbaru : Universitas Riau – FMIPA – Kimia., 2017

Deskripsi Fisik

xiv, 51 hlm.; ill.; 29 cm

Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

03 02. 117 (0087)

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

DAUS

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