CD Skripsi

Sintesis Dan Uji Toksisitas (E)-3-(4-((E)-((4-Hidroksifenil) Imino)Metil)Fenil)-1-(4-Metoksifenil)Prop-2-En-1-On

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Chalcone conjugate is a conjugate from two bioactive molecules to find a new molecule as a solution from resistance problem to drug. Chalcone conjugate has various biological activities, such as antibacterial, antimicrobial, biofilm, antiviral, antimycobacterial, antioxidant, anticancer, and antitumor. Chalcone conjugate (E)-3-(4-((E)-((4-hydroxyphenyl)imino)methyl)phenyl)-1-(4-methoxyphenyl)prop -2-en-1-one (KK-AF-4OMe) was synthesized from (E)-4-(3-(4-methoxyphenyl)-3-oxoprop-1-en-1-yl)benzaldehyde and 4-aminophenol by microwave irradiation method. The purity of the chalcone conjugate KK-AF-4OMe was determined by the TLC test, determination of melting point, and HPLC analysis. The structure of the chalcone conjugate KK-AF-4OMe was obtained from UV, FTIR, 1-H-NMR, and HRMS spectroscopic studies. Synthesis of chalcone conjugate KK-AF-4OMe in this research was concluded with a yield 31,3%, and the toxicity was determined by the Brine Shrimp Lethality Test (BSLT) method. The value of the LC50 was showed 4,811 µg/mL. From the data above was concluded that chalcone conjugate KK-AF-4OMe was toxic.

Keywords: chalcone conjugate KK-AF-4OMe, toxicity, Brine Shrimp Lethality Test (BSLT)

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

03 02. 120 (0016)

Penerbit

Pekanbaru : Universitas Riau – FMIPA – Kimia., 2020

Deskripsi Fisik

xiv, 38 hlm.: ill.: 29 cm

Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

03 02. 120 (0016)

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

ELFITRA

Versi lain/terkait

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