CD Skripsi

Hubungan Antara Polimorfise Gen Reseptor Vitamin D Dan Status Anti-Hepatitis B Surface Pada Mahasiswa Fakultas Kedokteran Universitas Riau

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Hepatitis B virus (HBV) is a virus that can infect parenchyme. HBV is transmitted through percutaneous contact and body fluids exposure from hepatitis B patients. Previous studies have shown levels of anti-hepatitis B surface (anti-HBs) have decreased by 15-20 years after 3 doses of hepatitis B vaccine and genetic factors are thought to influence the decrease in anti-HBs titers. This study aimed to analyze the relationship between vitamin D receptor (VDR) gene polymorphisms and the status of anti-Hepatitis B Surface (anti-HBs) among University of Riau medical students. This study included 80 medical students consisting of 40 non-protective anti-HBs and 40 protective anti-HBs. Analysis of VDR gene polymorphisms was conducted by Rapid Multiplex Amplification Refractory Mutation System-Polymerase Chain Reaction (Rapid ARMS-PCR). The results showed that VDR gene polymorphisms were predominantly bb for BsmI (78,8%), aa for ApaI (48,8%), TT for TaqI (87,5%) and Ff for FokI (66,3%). Chi-Square test showed a significant relationship between VDR gene polymorphism ApaI with anti-HBs status, namely individuals with AA + Aa genotype had a lower risk for decreased anti-HBs titer compared to those with aa genotype (OR 0.290; 95% CI: 0.116-0.727, p=0,014).Based on the ApaI polymorphism allele, individuals with allele A have a lower risk of OR 0,384 to experience non protective anti-HBs status compared to individual allele a (p=0,0011).

Keywords : Anti-HBs, Hepatitis B, VDR polymorphism

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

08 01.120 (0044)

Penerbit

Pekanbaru : Universitas Riau – Kedokteran – Pendidikan Dokter., 2020

Deskripsi Fisik

xiii, 54 hlm.: ill.: 29 cm

Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

08 01.120 (0044)

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

PENDIDIKAN DOKTER

Info Detail Spesifik

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Pernyataan Tanggungjawab

ELFITRA

Versi lain/terkait

Lampiran Berkas

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