CD Tesis

Sintesis Dan Uji In Silico Dengan Swissadme Senyawa 4-(3-(2-Kloropenil)-5-(2-Metoksipenil)-4,5-Dihidro-1h-Pirazol-1-Il) Benzenesulfonamida

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Natural of pyrazoline such as vitamins, alkaloids and pigments, but there are
limited availability, till synthesis is required. analog of Pyrazoline have biological
activity caused their substituents. Therefore, 4- (3- (2-chlorophenyl) -5- (2-
methoxyphenyl) -4,5-dihydro-1H-pyrazol-1-yl) benzenesulfonamide (1,3,5-triaryl
pyrazoline was synthesized 25) development by adding chlorophenyl, methoxyphenyl
and benzenesulfonamide to increase activity as an anticancer of the breast according
of reference. Furthermore, to determine its toxicity carried out using in silico test by
SwissADME and the results showed that the 1,3,5-triaryl pyrazoline 25 not toxic and
had potential as drug candidate. The rendemen of pure compound is 91% proven by
TLC test, melting point, HPLC and HRMS analysis. Confirmation the target molecule
using UV, FTIR, 1H-NMR, 13C-NMR and HRMS spectroscopy.
Keywords: Molecular confirmation, pure compound, pyrazoline, SwissADME,
synthesis of pyrazoline.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

10 05. 220 (0010)

Penerbit

Pekanbaru : Universitas Riau – Pascasarjana – Tesis Kimia., 2020

Deskripsi Fisik

xiii, 66 hlm,; ill.: 29 cm

Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

10 05. 220 (0010)

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

FATAH

Versi lain/terkait

Lampiran Berkas

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