CD Tesis

Sintesis Dan Uji In Silico Dengan Swissadme Senyawa Pirazolin (E)-7-(2-Metoksibenziliden)-3- (2-Metoksifenil)-5-Metil-2-Fenil-3,3a,4,5,6,7- Heksahidro-2h-Pirazolo[4,3-C]Piridin

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Pyrazoline is an azole group compound with a pentacyclic ring containing two nitrogen atoms. Pyrazoline with various biological activities has an important role in organic chemistry because of its application as a medicinal substance. In this case the pyrazoline compound (E)-7-(4-methoxybenziliden-3-(4-methoxyphenil)-5-methyl-2-phenil-3,3a,4,5,6,7-hexahydro-2H-pyrazolo[4,3-c] pyridine, has been successfully synthesized by reacting curcumin analogues with phenylhydrazine used an alkaline catalyst. The yield of the synthesis was 59%. The structures of were characterized by using UV spectroscopy, FTIR, 1H NMR and HRMS, confirming the compounds according to target compound. Then the in-silico test results using the SwissADME computational method, confirming that the pyrazoline compound that had been synthesized did not meet Lipinski's five rules, so it was toxic.
Key words: Curcumin, pirazoline, synthesis of pyrazoline, SwissADME

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

10 05. 220 (0011)

Penerbit

Pekanbaru : Universitas Riau – Pascasarjana – Tesis Kimia., 2020

Deskripsi Fisik

xiii, 46 hlm,; ill.: 29 cm

Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

10 05. 220 (0011)

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

FATAH

Versi lain/terkait

Lampiran Berkas

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