CD Skripsi

Sintesis Nanokitosan Menggunakan Metode Gelasi Ionik Dengan Variasi Konsentrasi Asam Formiat Dan Natrium Tripolifosfat

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ABSTRACT
Nanochitosan is widely developed as a drug delivery agent. Particles at the
nanometer scale have unique physical properties compared to particles at larger
sizes, especially in improving the delivery quality of drug compounds. The study
aims to synthesis nanochitosan using the ionic gelation method and determined
the effect of variations in the concentration of formic acid and concentration of
sodium tripolyphosphate (STPP) on the characteristics of nanochitosan. The
procedure for making nanochitosan is chitosan dissolved in formic acid by
stirring using a magnetic stirrer. After that, the STPP solution at the
chitosan:STPP 5:1 volume ratio was added to the chitosan solution. Stirring was
carried out for 1 hour with a stirring speed of 1200 rpm. Furthermore, the
nanochitosan was characterized by using Particle Size Analyzer (PSA), zeta
potential analyzer, Scanning Electron Microscopy (SEM), and Fourier Transform
Infrared (FTIR). Results of the research found that the polydispersity index of
chitosan-STPP particles was decreased when the concentration of formic acid
was increased, at the concentration of STPP (0.1%) and concentrations of formic
acid (0.2%; 1%; 2%) are 0.438; 0.436; 0.178 respectively. The particle size and
polydispersity index of chitosan-STPP particles were increased when the
concentration of STPP increased, at concentration of formic acid (2%) and
concentrations of STPP (0.1%; 0.5%; 1%) are 2508.5 nm; 2838.5 nm; 2869.9
nm; and 0.178; 0.354; 0.976 respectively.
Keywords: formic acid, ionic gelation, nanochitosan, sodium tripolyphosphate

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

07 02. 120 (0122)

Penerbit

Pekanbaru : Universitas Riau – Fakultas Teknik – Teknik Kimia., 2020

Deskripsi Fisik

xii, 29 hlm.; ill.: 29 cm

Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

07 02. 120 (0122)

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

TEKNIK KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

Daus

Versi lain/terkait

Lampiran Berkas

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