CD Skripsi

Sintesis Dan Uji Toksisitas Senyawa 1,2-Bis(Naftalen-1-Ilmetilen)Hidrazin

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Hydrazone is a versatile organic compound that has a basic structure (R1R2C=N-NR3R4). The active group of the hydrazone compound is azomethine (-NHN=CH-), which makes this compound the most important in the development of new medicines. In this research, the synthesis of the compound hydrazine 1,2-bis(naphthalene-1-ilmethylene)hydrazine (IHA-ND1) obtained from the condensation reaction between the 1-naphthaldehyde and hydrazine hydrate catalyzed by acetic acid. This compound was synthesized using a microwave irradiation method with 180 Watt. The purity of the compound was determined by TLC, melting point measurement, and HPLC analysis. The structure of the synthesized compound was confirmed through spectroscopic UV, FTIR, HR-MS, and NMR analysis. The results of this research were the IHA-ND1 compound successfully synthesized with a 54,87% yield. The bioactivity of the IHA-ND1 compound was evaluated its toxicity properties by the BSLT method. LC50 value of compounds IHA-ND1 is 47,20 μg/mL. It can be concluded that the compound IHA-ND1 is toxic, and further pharmacological tests can be carried out.
Keywords : azomethine, hydrazone, toxicity

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

03 02. 120 (0028)

Penerbit

Pekanbaru : Universitas Riau – FMIPA – Kimia., 2020

Deskripsi Fisik

xv, 28 hlm.: ill.: 29 cm

Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

03 02. 120 (0028)

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

ELFITRA

Versi lain/terkait

Lampiran Berkas

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