CD Skripsi

Sintesis Dan Uji Toksisitas Senyawa 5-(3-Klorofenil)-3-(Naftalen-2-Il)-1-Fenil-1h-Pirazol

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Pyrazole is a simple aromatic ring organic compound. Pyrazole is a 5 ring heterocyclic compound consisting of three carbon atoms and two nitrogen atoms in adjacent positions. Pyrazole has a wide range of biological and pharmacological activities. Chlorophenyl and naphtyl substituted pyrazole compounds was reported to have antifungal, antituberculosis and antiinflammatory bioactivity. In this study, the pyrazole analogue 5-(3-chlorophenyl)-3-(naphthalen-2-il)-1-phenyl-1H-pyrazole (PZL-2N-3Cl) was successfully synthesized from pyrazoline 5-(3-chlorophenyl)-3-(naphthalen-2-il)-1-phenyl-4,5-dihydro-1H-pyrazoline (PF-CN2-3Cl) with glacial acetic acid via oxidative aromatization reaction using reflux for 24 hours at a temperature of 85°C. The purity of the synthesized compound was determined using TLC and melting point. The structure of the synthesized compound was confirmed by UV, FTIR, HRMS and NMR spectroscopic analysis. The yield obtained from the synthesis of the PZL-2N-3Cl compound was 30,12%. The toxicity test of pyrazole compounds was determined by the BSLT method using shrimp larvae (Artemia salina Leach). Pirazol PZL-2N-3Cl is non-toxic with an LC50 value of = 4.634,4 μg / mL.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

03 02. 120 (0041)

Penerbit

Pekanbaru : Universitas Riau – FMIPA – Kimia., 2020

Deskripsi Fisik

xii,37 hlm.: ill.: 29 cm

Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

03 02. 120 (0041)

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

ELFITRA

Versi lain/terkait

Lampiran Berkas

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