CD Skripsi

Sintesis Dan Uji Toksisitas Analog Pirazol 5-(4-Fluorofenil)-3-(Naftalen-2-Il)-1-Fenil-1h-Pirazol

---

Pyrazole is five ring heterocyclic compounds with two adjacent nitrogen atoms and it has two endocyclic double bonds which are known to have diverse biological activities such as anti-inflammatory, analgesic, antibacterial, antimalarial, antioxidant, and anticancer. Pyrazole analogue 5-(4-fluorophenyl)- 3-(naphthalene-2-yl)-1-phenyl-1H-pyrazole (PZL-4F-AN2) was successfully synthesized through the synthesis of one-pot cyclization of pyrazoline which was then followed by oxidative aromatization reaction of pyrazoline 5-(4-fluorophenyl)-3-(naphthalene-2-yl)-1-phenyl-4,5-dihydro-1H-pyrazoline with glacial acetic acid by refluxing the mixture for 36 hours in an oli bath at 85oC . The purity of the compound was determined by using TLC, melting point, and HPLC analysis. The structure was confirmed using UV, FTIR, NMR, and HRMS spectroscopy analysis. The yield of the synthesized PZL-4F-AN2 compound was 18.29%. The toxicity of pyrazole was evaluated by Brine Shrimp Lethality Test (BSLT) method with shrimp larvae (Artemia salina Leach). Pyrazole PZL-4F-AN2 had high toxicity with LC50 = 43.07 µg/mL.
Keyword: acetic acid, pyrazole, reflux, toxicity

---

Ketersediaan

Informasi Detail

Judul Seri

-

No. Panggil

03 02. 120 (0043)

Penerbit

Pekanbaru : Universitas Riau – FMIPA – Kimia., 2020

Deskripsi Fisik

xv, 35 hlm.: ill.: 29 cm

Bahasa

Indonesia

ISBN/ISSN

-

Klasifikasi

03 02. 120 (0043)

Tipe Isi

-

Tipe Media

-

Tipe Pembawa

-

Edisi

-

Subjek

KIMIA

Info Detail Spesifik

-

Pernyataan Tanggungjawab

ELFITRA

Versi lain/terkait

Lampiran Berkas

Komentar

---

Anda harus masuk sebelum memberikan komentar