CD Skripsi

Sintesis Dan Uji Toksisitas 6-(4-Klorofenil)-4,5- Dihidropiridazin-3(2h)-On

---

Pyridazinone is a heterocyclic dinitrogen compound with one carbonyl which is known to have diverse biological activities such as anticonvulsant, analgesic, anti inflammatory, anti microbial, and anti hypertension. The pyridazinone 6-(4-chlorophenyl)pyridazin-3(2H)-one synthesized with 4-chloro acetophenone, glyoxylic acid and hydrazine hydrate by sealed-vessel reactor method. The purity of the pyridazinone was determined by the TLC test, determination of melting point, and HPLC analysis. The structure of the pyridazinone was obtained from UV, FTIR, NMR, and HRMS spectroscopic studies. Synthesis of 6-(4-chlorophenyl)-4,5dihydropyridazin-3(2H)-one in this research was concluded with a yield 60,52%, and the toxicity was determined by the Brine Shrimp Lethality Test (BSLT) method. The value of the LC50 was showed 7,01 µg/mL. From the data above was concluded that 6-(4-chlorophenyl)-4,5-dihydropyridazin-3(2H)-one conjugate was toxic.

---

Ketersediaan

Informasi Detail

Judul Seri

-

No. Panggil

03 02. 120 (0055)

Penerbit

Pekanbaru : Universitas Riau – FMIPA – Kimia., 2020

Deskripsi Fisik

xiv, 33 hlm.: ill.: 29 cm

Bahasa

Indonesia

ISBN/ISSN

-

Klasifikasi

03 02. 120 (0055)

Tipe Isi

-

Tipe Media

-

Tipe Pembawa

-

Edisi

-

Subjek

KIMIA

Info Detail Spesifik

-

Pernyataan Tanggungjawab

ELFITRA

Versi lain/terkait

Lampiran Berkas

Komentar

---

Anda harus masuk sebelum memberikan komentar