Image of Studi Molecular Docking Dan Sintesis Senyawapirazolin 3-(4-Klorofenil)-5-(3-Metoksifenil)-1-Fenil-4,5-Dihidro-Pirazol Sebagai Anti Kanker Payudara
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Studi Molecular Docking Dan Sintesis Senyawapirazolin 3-(4-Klorofenil)-5-(3-Metoksifenil)-1-Fenil-4,5-Dihidro-Pirazol Sebagai Anti Kanker Payudara

Pyrazoline is a five-ring heterocyclic compound with two nitrogen atoms close in its rings and has more than one endocyclic double bond. The availability of pyrazoline in nature in small amounts, but has a good biological activity in treating various diseases including as an anticancer or antidiabetic. This study aims to synthesize and confirm the activityof pyrazoline compunds. Pyrazoline compound 3-(4-chlorophenyl)-5-(3-methoxyphenyl)-1-phenyl-4,5-dihydro pirazol synthesized by one-pot reaction of three components between 3-methoxybenzaldehyde, 4-chloroacetophenone and phenylhydrazine with a base catalyst strong (NaOH), using the microwave irradiation method. The compound showed a sufficient yield of 65.68% and the structure of the pyrazoline compound was characterized using UV, FTIR, and 1H-NMR spectroscopy. The PF-4Cl-3OMe pyrazoline compound has been docked using the Molecular Operating Environment (MOE) program as an inhibitor of breast cancer and doxorubicin as a standard. The PF-4C-3OMe pyrazoline compound showed abinding free energy value of –11.60 kcal / mol higher than the doxorubicin standard of -12.89 kcal / mol and there was an interaction in the form of hydrogen bonds between the ligand and one of the active sites of the enzyme. These result indicate that the PF-4Cl-3OMe pyrazoline compound has potential as an inhibitor of breast cancer.
Keywords: anticancer, docking, pyrazoline

Ketersediaan
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Perpustakaan Universitas Riau 03 02. 120 (0069)
03 02. 120 (0069)
Tersedia
Informasi Detail
Judul Seri
-
No. Panggil
03 02. 120 (0069)
Penerbit
Pekanbaru : Universitas Riau – FMIPA – Kimia.,
Deskripsi Fisik
xi, 43 hlm.: ill.: 29 cm
Bahasa
Indonesia
ISBN/ISSN
-
Klasifikasi
03 02. 120 (0069)
Tipe Isi
-
Tipe Media
-
Tipe Pembawa
-
Edisi
-
Subjek
KIMIA
Info Detail Spesifik
-
Pernyataan Tanggungjawab
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Tidak tersedia versi lain

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