CD Skripsi

Sintesis Nanorod Emas Dan Potensi Aplikasinya Untuk Pengobatan Kanker Mulut

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Cancer is one of the leading causes of death in the world. One type of cancer is
oral cancer, which is difficult to diagnose at an early stage so that it is fatal and
can cause death. This study aims to synthesize and characterize gold nanorods and
to analyze the potential applications of gold nanorods in the treatment of oral
cancer cells. The method used to synthesize gold nanorods is the seed mediated
growth method (SMGM). Gold nanorods that have been successfully synthesized
were characterized using UV-Vis, XRD and FESEM spectroscopy to determine
their optical properties, structure, and morphologi respectively. The UV-Vis
absorbance spectra of the samples showed a peak of transverse surface plasmon
resonance (t-SPR) at a wavelength of 514 nm and a peak of longitudinal surface
plasmon resonance (l-SPR) at a wavelength of 686 nm. The diffraction pattern
from the XRD characterization results at the diffraction angle of 30° - 80°showed
4 diffraction peaks, namely at an angle of 2θ: 38,20°; 44,49°; 64,59°; and 77,72°.
Based on the results of the analysis using computer program called “High Scores”,
the four diffraction peaks correspond to the crystal planes (111), (200), (220), and
(311). Based on reference to standard data on inorganics crystal structure database
(ICDS) No. 98-061-1628, this diffraction pattern corresponds to the gold
diffraction pattern with a Face Centered Cubic (FCC) structure. The FESEM
photo shows the gold nanoparticles that have been synthesized have a geometric
shape in the form of nanorods, with an average length of 43.32 nm, a width of
17.91 nm and an aspect ratio of 2.49. The gold nanorod was trialed to treat oral
cancer cells carried out in several steps, namely cell culture, pre-treatment, and
treatment of oral cancer cells. The results of the treatment test using 1% gold
nanorod on oral cancer cells showed that gold nanorod could kill oral cancer cells
by 29.2%. This suggests that gold nanorods have a potential applications in oral
cancer treatment.
Keywords: Gold Nanorod, Characterization, Oral Cancer Treatment

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

03 01.120 (0078)

Penerbit

Pekanbaru : Universitas Riau – FMIPA – FISIKA., 2020

Deskripsi Fisik

xv, 55 hlm.: ill.: 29 cm

Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

03 01.120 (0078)

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

FISIKA

Info Detail Spesifik

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Pernyataan Tanggungjawab

ELFITRA

Versi lain/terkait

Lampiran Berkas

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