CD Skripsi

Sintesis Dan Uji Toksisitas Senyawa Analog Kurkumin Asimetris 1-Benzil-3-((E)-4-Klorobenziliden)-5-((E)-3-Metoksi benziliden) Piperidin-4-On

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SUMMARY
Curcumin is a compound diferuloylmethane and the related compoud are bioactive phytochemical compounds that are generally isolated from the rhizome of Curcuma Longa. L ( Tumeric ). Curcumin analogue compounds are compounds that have the same or even better pharmalogical propeties when compared to curcumin compounds. The asymmetric curcumin analogue 1-Benzyl-3-((E)-4-Chlorobenzyliden)-5-((E)-3-Methoxybenzyliden-Piperidine-4-On was synthesized by the One-Pot method through the Claisen schmidt reaction using base catalyst. The purity of the asymmetric curcumin analogue compound was determined by TLC test, melting point measurement and HPLC analysis. The structure of the synthesized compound was obtained from UV, FTIR, 1H-NMR and HRMS spectroscopy studies. In the synthesis of asymmetric curcumin analogue compounds, the yield was 4,77 % and the toxicity test of these compounds using the Brine Shrimp Lethality Test (BSLT) method, the LC50 value obtained was 6,83 μg/ml. Based on these result it can be concluded that the asymmetric curcumin analogue 1-Benzyl-3-((E)-4-Chlorobenzyliden)-5-((E)-3-Methoxybenzyliden-Piperidine-4-On is toxic.
Keywords : Asymmetric curcumin, Brine Shrimp Lethality Test (BSLT), toxicity

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

03 02. 121 (0009)

Penerbit

Pekanbaru : Universitas Riau – FMIPA – Kimia., 2021

Deskripsi Fisik

v, 107 hlm.: ill.: 29 cm

Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

03 02. 121 (0009)

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

ELFITRA

Versi lain/terkait

Lampiran Berkas

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