CD Skripsi

Sintesis Dan Uji Toksisitas Senyawa (E)-7-(2- Metoksibenziliden)-3-(2-Metoksifenil)-2-Fenil-3, 3A, 4, 5, 6, 7-Heksahidro-2h-Pirazolo [4,3C] Piridin

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SUMMARY
Pyrazoline is a dihydropyazole derivative which is included in the azole group of
compounds with a heterocyclic-5 structure containing 2 nitrogen atoms, has
various biological activities such as anticancer, antiinflation, antioxidants, and
antimalarials. The purpose of this study was to synthesize the analog compound
pyrazoline (E) -7- (2-methoxybenziliden) -3- (2-methoxyphenyl) -2-phenyl-3, 3a,
4, 5, 6, 7-hexahydro-2H-pyrazolo [4,3c] pyridine through the reaction of a
pipiridon derivative curcumin analogue with phenylhydrazine using a sodium
hydroxide catalyst. Curcumin compounds are obtained from a condensation
reaction between 4-piperidone monohydrate hydrochloride and 2-
methoxybenzaldehyde with a NaOH as catalyst. The pyrazoline were synthesized
via sealed vessel reactor with a stirring speed of 1000 rpm 80oC yield of 53.15%.
purity of the compound were analyzed using TLC, HPLC and melting point.
Identification of the structure of pyrazoline compounds by UV, FTIR, NMR, and
HRMS spectroscopy. The toxicity of pyrazoline compounds was tested by the
BSLT method using A. salina. The test results showed that the pyrazoline
compound is non-toxic with a value of LC50 = 674.06 μg / mL.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

03 02. 121 (0014)

Penerbit

Pekanbaru : Universitas Riau – FMIPA – Kimia., 2021

Deskripsi Fisik

v, 107 hlm.: ill.: 29 cm

Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

03 02. 121 (0014)

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

ELFITRA

Versi lain/terkait

Lampiran Berkas

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