CD Skripsi

Sintesis Dan Uji Toksisitas Senyawa Pirazolin 5-(4-Bromofenil)-3-(1-Hidroksinaftalen-2-Il)-1-Fenil-4,5-Dihidro-1h-Pirazol

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Pyrazoline is a secondary metabolic compound with five circular
heterocyclic structures that has three carbon atoms and two nitrogen atoms position
close to each other. Pyrazoline has high toxicity and possess various bioactivities
such as antitumor and anticancer agent. Pyrazoline (5-(4-bromophenyl)-3-(1-
hydroxynaphthalene-2-yl)-1-phenyl-4,5-dihydro-1H-pyrazole has successfully
synthesized with two phases of reaction. The reaction begins formation of chalcone
3-(4-bromophenyl)-1-(1-hydroxynaphthalene-2-yl)-2-propen-1-on by reacting 1-
hydroxy-2-acetylnaphthalene compound with 4-bromobenzaldehide. Chalcone
synthesis through claisen-schmidt condensation reactions with yield 85,86%. The
next step was reacted chalcone with phenilhydrazine to produce target compound
used sodium hydoxide catalyst. The target compound synthesis method was sealedvessel
reactor used monowave for 2 hours then produce yield 41,07%. Pyrazoline
compound ware purified by recrystallization then tested for purity with TLC test,
melting point and HPLC analysis and confirming its structure based on
spectroscopic data of UV, FTIR, 1H-NMR, 13C-NMR, HMBC and HRMS. The
synthesized product was screened for toxicity capability by brine shrimp lethality
test (BSLT) using Artemia salina Leach larvae. Pyrazoline compounds have LC50
value for pyrazoline are 8,38 μg/mL which can be interpreted as the synthesized
compounds are very toxic.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

03 02. 121 (0049)

Penerbit

Pekanbaru : Universitas Riau – FMIPA – Kimia., 2021

Deskripsi Fisik

xi, 59 hlm.: ill.: 29 cm

Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

03 02. 121 (0049)

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

ELFITRA

Versi lain/terkait

Lampiran Berkas

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