CD Skripsi

Sintesis Dan Uji Toksisitas Senyawa N'1,N'3-Bis ((E,E)-2-Fluorobenziliden)Malonohidrazid

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Hydrazone is a versatile of organic compounds with the structure R1C=N-NHR2.
Hydrazones containing an azomethine -NHN=CH- group which is known to possess
diverse biological activities such as anticancer, analgesic, antibacterial,
anticonvulsant, anti-inflammatory, and antimalarial. The addition of fluoro
substituents to the aromatic ring has been shown to improve the pharmacological
properties of hydrazone compounds. This study aimed to synthesize the compound
N'1,N'3-bis((E,E)-2-fluorobenzyliden)malonohydrazide (DB-2F) and the toxicity
test using the Brine Shrimp Lethality Test (BSLT) method. Novel compound
N'1,N'3-bis((E,E)-2-fluorobenzyliden)malonohydrazide (DB-2F) was synthesized
via condensation reaction of malonohydrazide and 2-fluorobenzaldehyde with
glacial acetic acid as catalyst. Synthesis of the compound used stirring and heating
(reflux) at 50-60oC. The purity of the compound was determined using TLC,
melting point, and HPLC. The structure of synthesized compound was confirmed
by UV, FTIR, NMR and HRMS spectroscopy studies. The yield of the synthesis
DB-2F compound was 59.73%. The toxicity of DB-2F compound was evaluated by
Brine Shrimp Lethality Test (BSLT) method with shrimp larvae Artemia salina
Leach. The result of the test showed DB-2F compound is toxic with LC50 = 175.792
μg/mL.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

03 02. 121 (0057)

Penerbit

Pekanbaru : Universitas Riau – FMIPA – Kimia., 2021

Deskripsi Fisik

x, 32 hlm.: ill.: 29 cm

Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

03 02. 121 (0057)

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

ELFITRA

Versi lain/terkait

Lampiran Berkas

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