CD Skripsi

Sintesis Dan Uji Toksisitas Senyawa N'1,N'3-Bis ((E,E)-3-Bromobenziliden)Malonohidrazid

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Hydrazone is a substitution product of stable imine type which has a basic
structure (R1-HC=N-NH-R2). The izometine (-HC=N-NH-) group in hydrazones
plays a role in their biological activity for the design and development of drugs. In
this study, the synthesis of the compound synthesized N'1,N'3-bis
((E,E)-3-bromobenzilydene)malonohydrazide (DB-3Br) was from the
condensation reaction between malonohydrazide and 3-bromobenzaldehyde
catalyzed by acetic acid. This compound was synthesized using the
method of stirring and heating (reflux) at a temperature of 50-60℃. The purity of
the compound was determined using the TLC test, melting point measurement,
and HPLC analysis. The structure of the synthesized compound was confirmed by
UV, FTIR, HRMS, and NMR spectroscopic analysis. The result of this
research is that the compound DB-3Br was successfully synthesized with a yield
of 71,76%. The bioactivity of the compound was DB-3Br tested for its toxicity
using the BSLT method. LC50 value of the compound was 48,881 μg/mL.
So it can be concluded that the compound DB-3Br is toxic and can be carried out
further pharmacological test.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

03 02. 121 (0059)

Penerbit

Pekanbaru : Universitas Riau – FMIPA – Kimia., 2021

Deskripsi Fisik

x, 31 hlm.: ill.: 29 cm

Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

03 02. 121 (0059)

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

ELFITRA

Versi lain/terkait

Lampiran Berkas

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