CD Skripsi

Sintesis Dan Uji Toksisitas Senyawa N’1,N’3-Bis((E,E)-4-Fluorobenziliden)Malonohidrazid

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Hydrazone is a versatile compound in drug design for the synthesis of
heterocyclic compounds with different biological activities because it has two
active centers, namely two nitrogen atoms and two carbon atoms. Hydrazones
play an important role in heterocyclic structures where hydrazones can be used as
intermediates to synthesize heterocyclic compounds. The combination of
hydrazones with other functional groups produces compounds with unique
physical and chemical properties. The addition of a fluoro group in a compound
can have a significant effect and can increase the activity of the compound. Some
of the pharmacological activities of hydrazone compounds include antimicrobial,
antiviral, anticancer and others. The aim of this study is to synthesize the
compound N'1,N'3-bis((E,E)-4-fluorobenzyliden)malonohydrazide which has a
good toxicity value. The compound N'1,N'3-bis((E,E)-4-fluorobenzyliden)
malonohydrazide was synthesized by condensation reaction between
malonohydrazide and 4-fluoro benzaldehyde using glacial acetic acid as catalyst.
Synthesis of compound N'1,N'3-bis((E,E)-4-fluorobenzyliden)malonohydrazide
using reflux with heating and stirring method. The purity test for this compound
was determined using the TLC test, melting point determination and HPLC
analysis. The structure of the compound was identified using spectroscopic
analysis of UV, FTIR, NMR and HRMS. The yield obtained from the synthesis
was 67.79%. The toxicity test of the compound was carried out using the Brine
Shrimp Lethality Test (BSLT) method and the results showed that this compound
was toxic with an LC value of50 = 125.02 g/mL.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

03 02. 121 (0062)

Penerbit

Pekanbaru : Universitas Riau – FMIPA – Kimia., 2021

Deskripsi Fisik

x, 29 hlm.: ill.: 29 cm

Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

03 02. 121 (0062)

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

ELFITRA

Versi lain/terkait

Lampiran Berkas

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