CD Skripsi

Sintesis Dan Uji Toksisitas Analog Kurkuminasimetris 1-Benzil-3-((E)-2-Klorobenziliden)-5-((E)- 4-Metoksibenziliden)Piperidin-4-On

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Curcumin is one of the secondary metabolites that chemically belongs to the phenolic
group. Curcumin has long been known as a yellow substance in the rhizomes of
Zingiberaceae, which are used as traditional medicine in Asia. Curcumin analogues
may have the same or even better pharmacological properties. The asymmetric
curcumin analogue compound 1-benzyl-3-((e)-2-chlorobenzyliden)- 5-((e)-4-
methoxybenzyliden) piperidine-4-one was synthesized by themethod One- Pot
through the Claisen Schmidt reaction using an alkaline catalyst. The purity of the
asymmetric curcumin analog compound was determined by TLC test, melting point
measurement and HPLC analysis. The structure of the synthesized compound was
obtained from UV, FTIR, 1H-NMR, and HRMS spectroscopic studies. In the synthesis
of asymmetric curcumin analogue compounds, the yield was 3.47% and the toxicity
test of this compound was done through the Brine Shrimp Lethality Test (BSLT)
method. The LC50 value obtained was 173.78 g/ml, there for it can be concluded that
the asymmetric curcumin analog compound 1-benzyl-3-((e)-2- chlorobenzyliden)-5-
((e)-4-methoxybenzyliden) piperidine-4-one is toxic.
Keywords : Asymmetric curcumine, Brine Shrimp Lethality (BSLT), toxicity

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

03 02. 121 (0065)

Penerbit

Pekanbaru : Universitas Riau – FMIPA – Kimia., 2021

Deskripsi Fisik

xiv, 34 hlm.: ill.: 29 cm

Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

03 02. 121 (0065)

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

ELFITRA

Versi lain/terkait

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