CD Skripsi

Sintesis, Uji Aktivitas Dan Molecular Docking Senyawa Pirazolindan Pirazol Turunan 2-Metoksifenil Dan 3- Hidroksibenzaldehidterhadap Inhibitor Enzim Tirosinase

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Pyrazoline and pyrazole are heterocyclic compounds containing two
nitrogen atoms which have various bioactivities such as antidiabetic,
anticancer, antibacterial, and tyrosinase inhibitors. Pyrazoline
compounds and pyrazole derivatives of 2-methoxyphenyl and 3-
hydroxybenzaldehyde were synthesized in three steps. The firststage is
the formation of chalcone compounds using a microwave device, the
second stage is the formation of pyrazoline compounds using a
monowave device, and the third stage is the formation of pyrazole
compounds using a reflux device. The purity of the target compound
was then analyzed by TLC test, melting point measurement, and HPLC.
The synthesized compound was then confirmed its structure through UV
spectroscopy, FTIR, 1 H-NMR, and HRMS. These compounds were
tested for their activity as tyrosinase inhibitors through molecular
docking and in vitro tests. The activity of the target compound was
compared with kojic acid as a positive control. The test results showed
that the pyrazoline target compound had a free bond energy(S score) =
-11.0581 kcal/mol while the pyrazole target compound had a free bond
energy (S score) = -11.0446 kcal/mol. If viewed from the positive
control, namely kojic acid which has a bond free energy (S score) =
-8.7148 kcal/mol, the synthesized pyrazoline and pyrazole compounds
have the potential as tyrosinase inhibitor compounds. In vitro test results
showed that the target compound pyrazoline had an IC50 value of
1282,023 μg/mL while the pyrazole compound had an IC50 value of
217.434 μg/mL, and kojic acid compounds had an IC50 value of 12.58
μg/mL, pyrazoline and pyrazole compounds. Synthesized pyrazoline
and pyrazole compounds are weak inhibitors in inhibiting the tyrosinase
enzyme because pyrazoline and pyrazole compounds have not been able
to match kojic acid in inhibiting the tyrosinase enzyme.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

03 02. 121 (0074)

Penerbit

Pekanbaru : Universitas Riau – FMIPA – Kimia., 2021

Deskripsi Fisik

xi, 50 hlm.: ill.: 29 cm

Bahasa

Indonesia

ISBN/ISSN

-

Klasifikasi

03 02. 121 (0074)

Tipe Isi

-

Tipe Media

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Tipe Pembawa

-

Edisi

-

Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

ELFITRA

Versi lain/terkait

Lampiran Berkas

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