Background: Mesenchymal stem cells (MSCs) have great potential for therapy due to their self-renewal, differentiation and immunoregulatory capacities. The proliferative and functional activity of MSCs as well as its immunomodulatory properties can be impaired as a result of oxidative stress-induced senescence during long-term culture of MSCs. Modification of MSCs culture is very important to im…
VITRIYANNA MUTIARA YUHENDRI. NIM. 2110247804. The Effect of Vitamin D Preconditioning on Biological Characteristics and Expression of Tumor Necrosis Factor-α, Interleukin-6, Vascular Endothelial Growth Factor in Mesenchymal Stem Cells. supervised by Arfianti and Ismawati. Background: Mesenchymal stem cells (MSCs) have great potential in regenerative medicine applications. Vitamin D has immuno…
NURUL AZIZAH, Student ID: 2210246766, The Anti-Inflammatory Effect of Metformin Through Modulation of Cyclooxygenase-2 (COX-2) and Interleukin-10 (IL-10) in a Hemorrhoid Rat Model, supervised by Dr. Darmawi M.Biomed., PhD, and Dr. M. Yulis Hamidy, M.Kes, M.Pd.Ked., Sp.K.K.L.P. Background: Hemorrhoids are a medical condition characterized by inflammation and dilation of blood vessels around the…
Hemorrhoids are a condition characterized by the dilation of venous blood vessels in the anorectal region, involving inflammation, thrombosis, and bleeding. Anti-inflammatory treatments are crucial in preventing the progression of hemorrhoids. Metformin, primarily used as an antihyperglycemic drug, also has anti-inflammatory properties. Its use in patients with type 2 diabetes shows potential i…
Introduction: Diterpene quinone-derived compounds are proven to have antibacterial activity. However, their mechanism of action is unknown. This study aims to determine the mechanism of antibacterial action of a diterpene quinone derivatives (67DOR, 6O7AR) on S. aureus and E. coli through in vitro and in silico assays. Methods: This study is a laboratory experimental through in vitro and in si…