CD Skripsi

Sintesis Dan Studi Molecular Docking Senyawa Kalkon (E)-3-Fenil-1-(3-(4-(Pirolidin-1-Il) Butoksi)Fenil)Prop-2-En-1-On Sebagai Inhibitor Enzim Tirosinase

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SUMMARY
Chalcones are composed of two benzene rings connected by a carbon α,β-
unsaturated carbonyl structure and has various bioactivity, such as antibacterial,
anticancer, antioxidant and inhibitor tyrosinase. For the further development of
chalcone compounds, this research has carried out the synthesis of chalcone
derivatives and the determination of their activity as a tyrosinase inhibitor through
the in silico (molecular docking) approach. This chalcone derivative was
synthesized by Claisen-Schmidt condensation between benzaldehyde and 3-
hydroxyacetophenone. The chalcone compound was reacted with 1,4-
dibromobutane and followed by a substitution reaction of the bromo with the
pyrolidine. The structure of synthesized compounds were confirmed by
spectroscopy analysis of UV, FTIR, 1H-NMR and HRMS. The compound was
tested for their activity as a tyrosinase inhibitor through molecular docking.
Molecular docking studies were carried out on the crystal structure of tyrosinase
(PDB ID: 2Y9X) and kojic acid as positive control. This target compound shows
the free energy binding (S score) of -13.6379 kcal/mol, while kojic acid has a
higher value of -8.3470 kcal/mol. The lower free energy binding value, the better
compound were used in inhibiting of tyrosinase enzyme. This is also due to the
interaction of the target compound with the amionic acid were similar as the
innate ligand (tropolone) in the protein. Thus, it can be seen that the Kalkon (17)
compound is thought to be potential candidates for tyrosinase inhibitors.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

03 02. 121 (0028)

Penerbit

Pekanbaru : Universitas Riau – FMIPA – Kimia., 2021

Deskripsi Fisik

v, 107 hlm.: ill.: 29 cm

Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

03 02. 121 (0028)

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

ELFITRA

Versi lain/terkait

Lampiran Berkas

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