CD Skripsi

Efek Pemberian Akrilamida Terhadap Histologi Ginjal Tikus Putih Wistar Rattus Norvegicus (Berkenhout, 1769)

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Acrylamide is a hazardous chemical compound formed in food through high- temperature cooking processes, particularly in foods rich in carbohydrates and proteins. This compound is toxic, carcinogenic, and neurotoxic, and may trigger kidney damage. This study aimed to determine the effect of acrylamide administration on the histological structure of the kidneys in Wistar rats (Rattus norvegicus B.). The experimental groups consisted of P0 (control), P1 (2.5 µg/kg BW), P2 (5 µg/kg BW), and P3 (10 µg/kg BW). Histological preparations were made using the paraffin method and observed microscopically with Hematoxylin- Eosin staining. The results showed structural damage in the glomerulus, proximal convoluted tubules, Loop of Henle, and distal convoluted tubules, including parenchymal degeneration, hydropic degeneration, fatty degeneration, and necrosis. The highest percentage of necrosis was found in the P3 group, with 51.19% in the proximal convoluted tubules and 50.89% in the distal convoluted tubules, categorized with a score of 3 (severe damage). In the P1 group, necrosis reached 33.95% in the proximal convoluted tubules and 34.87% in the distal convoluted tubules, while in the P2 group, necrosis reached 47.68% and 45.62% respectively, both classified with a score of 2 (moderate damage). The higher the acrylamide dose, the more severe the tissue damage and the lower the percentage of normal kidney cells. These findings indicate that acrylamide exposure has the potential to significantly damage kidney histological structures.

Key findings: acrylamide, histology, kidney structure, Wistar rats.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

2003112676

Penerbit

Pekanbaru : Universitas Riau FMIPA Biologi., 2025

Deskripsi Fisik

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Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

2003112676

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

BIOLOGI

Info Detail Spesifik

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Pernyataan Tanggungjawab

ERA

Versi lain/terkait

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