CD Skripsi

Isolasi Senyawa Metabolit Sekunder Ekstrak Etil Asetat Dan Uji Aktivitas Antijamur Dari Tumbuhan Lycopodiella Cernua (L.) Pic. Serm.

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Lycopodiella cernua L., commonly known as the wire fern and classified under the Lycopodiaceae family, has been reported to possess potential as a source of bioactive compounds, particularly with antifungal properties. This study aims to isolate bioactive constituents from L. cernua and to identify compounds with potential antifungal activity. Extraction was performed using a sequential maceration technique with four solvents of increasing polarity. The ethyl acetate extract, weighing 32.98 g, was selected for further separation using the Vacuum Liquid Chromatography (VLC) method, as it was presumed to contain polar to semi-polar compounds exhibiting biological activity. From the ethyl acetate extract, a pure compound was successfully isolated and designated as PK_EAF1_SF11. The compound was obtained as a yellowish-green solid with a mass of 110 mg. Spectroscopic analyses, including UV-Vis, FTIR, and LC-MS/MS, revealed that the compound exhibited a molecular ion [M+H]+ at m/z 743.36 and is thought to be troxerutin, a flavonoid belonging to the flavonol subclass. The antifungal activity assay demonstrated that the PK_EAF1_SF11 compound exhibited a Minimum Inhibitory Concentration (MIC) of 200 ppm against C. albicans, C. glabrata, and C. krusei. The Minimum Fungicidal Concentration (MFC) against C. glabrata and C. krusei was found to be >200 ppm, indicating fungistatic activity, as it inhibits fungal growth without killing the organisms. In contrast, the MFC against C. albicans was 200 ppm, suggesting fungicidal activity, as the compound was capable of killing this fungal species.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

2103135501

Penerbit

Pekanbaru : Universitas Riau FMIPA Kimia., 2025

Deskripsi Fisik

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Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

2103135501

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

Mutia

Versi lain/terkait

Lampiran Berkas

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