CD Skripsi
Uji Aktivitas Antimikroba Ekstrak Metabolit Sekunder Fungi Endofit Mangifera Foetida Terhadap Beberapa Mikroba Patogen
Microbial infections caused by pathogenic microbes have become an increasingly serious global health concern, particularly due to the rise of microbial resistance to antibiotics. An alternative solution is being explored by investigating bioactive compounds from endophytic fungi of mango macang (Mangifera foetida), which are capable of producing secondary metabolites with potential antimicrobial activity. This study aimed to test the antimicrobial activity of secondary metabolite extracts from endophytic fungi against the growth of pathogenic microbes. The testing of fungal isolates was conducted using the Kirby-Bauer method (disc diffusion). The results showed that isolate JK 1 exhibited antimicrobial activity categorized as intermediate against Escherichia coli at a 50% concentration, with an inhibition zone diameter of 13.20 mm. Isolate JD 3 showed the highest activity against Staphylococcus aureus at the same concentration, with an inhibition zone diameter of 5.93 mm, categorized as resistant. Isolate JK 3 demonstrated low antimicrobial activity (resistant) against all tested microbes at concentrations of 10%, 30%, and 50%, with small inhibition zones. Isolate JD 1 showed resistant- level activity against Propionibacterium acnes and Candida albicans at a 50% concentration, with inhibition zones of 5.38 mm and 5 mm.
Key findings: Antimicrobial activity, endophytic fungi, Mangifera foetida, pathogenic microbes, secondary metabolites
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