CD Skripsi

Perbandingan Metode Isolasi Senyawa Diterpenoid Abietan Pada Daun Bangun-Bangun Segar (Plectranthus Amboinicus)

---

Plants of the genus Plectranthus (family Lamiaceae) are an interesting source of abietan diterpenoid compounds. One important species of this genus is Plectranthus amboinicus, an herbal plant that grows naturally in tropical and warm temperate regions, such as in Africa, Asia, and Australia. One of the major compounds found in Plectranthus is royleanone, which belongs to the class of abietan diterpenoids. This compound has promising pharmacological activities, especially as an antiproliferative agent, making it interesting to be studied further in drug development. This study aims to determine the efficiency of selecting extraction methods and types of solvents in isolating abietan diterpenoid compounds. Isolation was carried out using conventional maceration and sonication-assisted maceration methods, four types of solvents were used in this study which were n-hexane, dichloromethane, ethyl acetate, and methanol. Standard solutions of 7-acetoxy-6-hydroxy royleanone were prepared with graded concentrations (1250 to 78,125 ppm) and injected into the HPLC instrument to obtain retention times and create calibration curves. The calibration curve showed good linearity with regression equation y = 2220.18x + 112481 and R² value = 0.9781. Identification of compounds in P. amboinicus extract was carried out based on the conformity of retention time with the standard. The quantification results showed that in the conventional maceration method, the ethyl acetate extract had the highest concentration of 639.728 ppm followed by dichloromethane, n-hexane, and methanol. Meanwhile, in the sonication-assisted maceration method, there was an increase in the concentration of compounds in all solvents, with ethyl acetate extract still showing the highest result of 989.749 ppm. This indicates that sonication increases the extraction efficiency of the target compounds.

---

Ketersediaan

Informasi Detail

Judul Seri

-

No. Panggil

2103111752

Penerbit

Pekanbaru : Universitas Riau FMIPA Kimia., 2025

Deskripsi Fisik

-

Bahasa

Indonesia

ISBN/ISSN

-

Klasifikasi

2103111752

Tipe Isi

-

Tipe Media

-

Tipe Pembawa

-

Edisi

-

Subjek

KIMIA

Info Detail Spesifik

-

Pernyataan Tanggungjawab

Mutia

Versi lain/terkait

Lampiran Berkas

Komentar

---

Anda harus masuk sebelum memberikan komentar