CD Skripsi

Pengaruh Asam Alfa Lipoat Terhadap Kadar Kolesterol Total Pada Tikus Diabetes Melitus Tipe 2

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Hypercholesterolemia is complication in type 2 diabetes. Alpha lipoic acid (ALA) can reduce total cholesterol by modulating cholesterol synthesis pathway and reduced cholesterol biosynthesis genes expression. The goal of this research was to investigate prohibition of hypercholesterolemia in type 2 diabetes rat by ALA. Fifteen adult male wistar rats (2-3 months 200-250 g body weight) were segregated into three groups labelled as standard (standard diet), type 2 diabetes (induced by streptozotocin 50 mg/kg weight and nicotinamide 110 mg/kg weight intraperitoneally) and type 2 diabetes + ALA (ALA 60 mg/kg weight by sondage given for 3 weeks after type 2 diabetes induced). The diagnosis of type 2 diabetes was defined if random blood glucose was measured 250 mg/dl at third day of induction. Rats terminated after 31 days and total cholesterol was measured by enzymatic method. The results showed that there were significant difference between ALA and type 2 diabetes groups (p= 0.012), and there were no significant difference between ALA and standard groups (p= 0.591). As the conclusion, this study proved that ALA had effect to decrease on total cholesterol in type 2 diabetes rats.
Key Words: alpha lipoic acid, type 2 diabetes, total cholesterol

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

08 01. 118 (0025)

Penerbit

Pekanbaru : Universitas Riau – Fakultas Kedokteran – Pendidikan Kedokteran., 2018

Deskripsi Fisik

xiii, 56 hlm.; ill.; 29 cm

Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

08 01. 118 (0025)

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

PENDIDIKAN KEDOKTERAN

Info Detail Spesifik

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Pernyataan Tanggungjawab

DAUS

Versi lain/terkait

Lampiran Berkas

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