CD Skripsi

Efek Pemberian Asam Α-Lipoat Pada Histopatologi Aorta Torakalis Tikus Diabetes Melitus Tipe 2

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Atherosclerosis is arterial wall’s disease initiated by lipid retention, oxidation, and modification, provoking chronic inflamation ultimately causing stenosis and thrombosis. Alpha-lipoic acid (ALA) is naturally found in mitochondria that exerts anti-oxidant and anti-inflamatory effect associated with abnormal oxidative stress and inflamation on diabetes melitus (DM) . This study investigated the effect of ALA on thoracic aorta of type 2 diabetic rat. Fifteen adult male rat of Rattus novergicus Wistar strain were separated into three groups (n=5), there were labelled as control, type 2 diabetes, and DM + ALA. Type 2 diabetic rat were induced by streptozotocin (50 mg/kg bodyweight) and nicotinamide (110 mg/kg bodyweight) intraperitoneal and categorised as diabetic rat if blood glucose level >250 mg/dl. Alpha lipoic acid was administered via intraperitoneal (60 mg/kg/day) and conducted for 3 weeks. The measured parameter was atherosclerosis lesion score. Results showed that there was no significant difference of atherosclerosis lesion score between all group designed (p=0,071). it can be concluded that ALA did not have significant effect on atherosclerosis lesion of thoracic aorta diabetic rat.
Keywords: alpha-lipoic acid, atherosclerosis, atherosclerosis lesion score, diabetes melitus, nicotinamide, streptozotocin

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

08 01. 118 (0029)

Penerbit

Pekanbaru : Universitas Riau – Fakultas Kedokteran - Pendidikan Kedokteran., 2018

Deskripsi Fisik

xv, 37 hlm.; ill.; 29 cm

Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

08 01. 118 (0029)

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

PENDIDIKAN KEDOKTERAN

Info Detail Spesifik

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Pernyataan Tanggungjawab

DAUS

Versi lain/terkait

Lampiran Berkas

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