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Ketepatan Penyesuaian Dosis Antibiotik Berdasarkan Nilai Bersihan Kreatinin Pada Pasien Geriatri Yang Dirawat Di Ruang Rawat Intensif Rsud Arifin Achmad Provinsi Riau Tahun 2016
Geriatric patients experience a decrease in the physiological function of one of the kidneys. Creatinine clearance is a parameter used to assess the decline in kidney function. The inappropriate use of antibiotics may result in a minimal therapeutic effect or toxicity. This study aims to obtain a description of the accuracy of doses of antibiotics in geriatric patients based on creatinine clearance value calculated by Cockcroft-Gault Formula in the intensive care unit of Arifin Achmad General Hospital of Riau Province 2016. This research is a retrospective descriptive research using secondary data in the form of medical record. The sample used was 50 which has been in accordance with the inclusion criteria. The number of male patients was 2 times more than women with the most age group is ≥ 65 years (80%). The average body weight of male patients is 63 kg and in women 55.8 kg. The most common diagnosis is infection (36,3%). The average serum creatinine of male patients was 2,8 mg/dL and in women 2,1 mg/dL. Most patients had a creatinine clearance rate of> 50 mL / minute (62%) and the rest decreased renal function. The most widely used group of antibiotics is cephalosporins (40%). Adjustment of antibiotic dose adjustment was found as much as (80.7%) while the remaining use was in excessive dosage. The types of antibiotics used with the most excess doses are meropenem and amikacin. Given the risk of toxicity due to decreased renal function in geriatric patients, the clinician should be careful of the dose of antibiotics given.
Keywords: accuracy, antibiotics, Cockcroft-Gault, creatinine clearance, dosage, geriatric
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