CD Skripsi

Analisis Data Dan Karakterisasi Potensi Tiga Varietas Macang (Mangifera Foetida L) Terhadap Virus Dengue Secara In Vitro

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ABSTRACT
Macang (Mangifera foetida L) is rarely cultivated by the community and has a low economic value due to its sour fruit taste, coarser fibre and more sap than other species of mangoes. The new discovery about the potential of macang as an antiviral will help conservation efforts of macang in nature while maintaining and increasing its biodiversity value. This study aims to analyze data and characterize the in vitro potential of three varieties of macang against the dengue virus. Three varieties of macang analyzed were Limus, Manis and Batu varieties. Dengue virus is infected in Vero cells, viral replication was measured using the Viral ToxGlo Assay method. The selectivity ability of macang stem bark extract to inhibit the dengue virus was seen from the Selectivity Index (SI) value. The SI value is obtained from the value of half-maximal cytotoxicity concentration (CC50) divided by the value of half-maximal inhibitory concentration (IC50). The standard curve between the concentration of the compound (μg/mL) and % cell viability was analyzed by linear regression using Microsoft Excel 2010 software. The results showed that the IC50 value of the macang stem bark extract of Limus, Manis and Batu varieties was 18.69, 10.46 and 8.14, respectively. The CC50 values were 141.68, 71.36 and 133.78, respectively. The selectivity index (SI) values were 7.58, 6.82 and 16.43, respectively. It was concluded that the extract of macang stem bark of the Limus, Manis and Batu varieties had the potential to be used as an antiviral for dengue.
Keywords: Characterization, Mangifera foetida L, Dengue Virus, Vero Cells

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

03 04. 121 (0031)

Penerbit

Pekanbaru : Universitas Riau - Fakultas Matematika Dan Ilmu Pengetahuan Alam - Biologi., 2021

Deskripsi Fisik

v, 107 hlm.: ill.: 29 cm

Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

03 04. 121 (0031)

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

BIOLOGI

Info Detail Spesifik

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Pernyataan Tanggungjawab

ELFITRA

Versi lain/terkait

Lampiran Berkas

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