CD Skripsi

Sintesis Dan Uji Toksisitas Senyawa Analog Kalkon (2e,2’e)-3,3’-(1,4-Fenilen)Bis (1-(2-Metoksifenil)Prop-2-En-1-On

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ABSTRACT
Chalcone is a secondary metabolite which include flavonoid group, it can be obtained from plants or synthesis. Chalcone analogues have been reported to possess various biological activities such as antibacterial, antifungal, anti-inflammatory, antioxidant and anticancer. Activities of chalcone was affected by α, β-unsaturated of carbonyl group and substituents that attached to the aromatic rings. Generally, chalcone analogues can be synthesized via Claisen–Schmidt condensation. In this study, the analogue of chalcone (2E,2’E)-3,3’-(1,4-phenylene)bis(1-(2-methoxyphenyl)prop-2-en-1-one has been successfully synthesized by reacting 2’-methoxyacetophenone and terephtalaldehyde in basic condition with 25,5% yield. The structure of compound was characterized by UV, FTIR, 1H-NMR and HRMS. In addition, the toxicity of chalcone analogue were also investigated by Brine Shrimp Lethality Test method and the test results indicated that the compound was not have toxicity activities, was proved with LC50 value of > 1000 μg/mL.
Keywords : Brine Shrimp Lethality Test, chalcone, Claisen-Schmidt, toxicity.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

03 02. 116 (0015)

Penerbit

Pekanbaru : Universitas Riau – FMIPA – Kimia., 2016

Deskripsi Fisik

xiii, 47 hlm.: ill.: 29 cm

Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

03 02. 116 (0015)

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

JAKA

Versi lain/terkait

Lampiran Berkas

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