Sintesis Dan Uji Toksisitas Senyawa Analog Kurkumin 1-(3-Kloropropil)-3,5-Bis…

Curcumin is a secondary metabolite that has diverse biological activities. However, curcumin has low bioavailability due to the presence of the β-diketone unit is easily hydrolyzed at physiological pH. Therefore the replacement of the unit with monoketone is expected to overcome this problem. We hereby report the synthesis of the piperidone derivative monoketone curcumin analogs. Synthesis was…