Curcumin is a secondary metabolite that has diverse biological activities. However, curcumin has low bioavailability due to the presence of the β-diketone unit is easily hydrolyzed at physiological pH. Therefore the replacement of the unit with monoketone is expected to overcome this problem. We hereby report the synthesis of the piperidone derivative monoketone curcumin analogs. Synthesis was…
Jelutung (Dyera costulata) is a plant of the Apocynaceae family which is found in the Talang Mamak tribal, Kelayang District, Indragiri Hulu Regency, Riau Province. It is usually used by the Talang Mamak tribe as a medicinal plant to treat various diseases such as skin diseases, digestive infections, and throat infections (coughing). The plant contains secondary metabolites such as alkaloids, f…
Pyrazoles are well known heterocyclic azo compound due their various biological activity such as antioxidant, antimicrobial, antitubercular, antiinflamation and anticancer. This research aims to synthesize 1,3,5-triaryl pyrazole derivatives containing sulphonamide and morpholine moeity and determine their anti-breast cancer activity. 1,3,5-Triaryl pyrazole derivatives were synthesized through m…
Diabetes is a disease which characterized by hyperglycemia caused by abnormalities of insulin. To treat this disease is to use natural product such as plant. Medicinal plants have long been used by Indonesian people, especially by the Talang Mamak tribe who live around Indragiri Hulu Regency, Riau Province. One of the plants used as traditional medicine is tunjuk langit. This study was to isola…
Laccase (benzenediol: oxygen oxidoreductase, EC 1.10.3,2) is an important industrial enzyme used in the paper, food and textile industries. It is produced by many different organisms, including filamentous fungi. Trichoderma asperellum LBKURCC1 is a strain isolated from Riau soil, which can produce laccase by solid state fermentation (SSF) of rice husk and rice straw. The aim of this work was t…
The problems were facing by PT. IKPP Perawang are high coal fly ash and paper bulk (volume/weight) of print paper. The content of silica on the coal fly ash (CFA) used as raw material to prepare paper filler. Silica from this CFA was optimized by various concentration of sodium hidroxide (1, 2, 3, 4 & 5N), reaction time (1,2, 3 & 4 h), mass ratio of fly ash to NaOH (1 :3, 1:4, 1:5, 1:6) and sti…
The development of heterogeneous base catalysts for biodiesel production by the transesterification reaction becomes favorite one because more environmentally friendly, more easily be separated from the rest of the processing biodiesel, and can be reused in order to reduce the cost of production biodiesel. Heterogeneous base catalyst often used to transesterification reaction is calcium oxide …
Two pyrazoline analogs 3- (2-methoxy-phenyl) -5-naphthalene-1-yl-1-phenyl-4,5-dihydro-pyrazole (PF CL-2OMe) and 3-(2-methoxy-phenyl)-5-naphthalene-1-yl-4,5-dihydro-1H-pyrazole (PH CL-2OMe) were synthesized by cyclisation reaction between the (E)-1-(2-methoxy-phenyl)-3-naphthalene-1-yl-propenone (CL-2OMe) and two hydrazine derivatives, phenylhydrazine and hydrazine hydrate using a basic catalyst…
Almost all the dyes used in the textile and textile products industry is a synthetic dye. The is most often used are azo dyes. The liquid waste dye generated will cause environmental pollution and are likely to be carcinogenic. Liquid waste dye can be degraded by using microorganisms such Trichoderma asperellum LBKURCC1 which capable to degrade azo direct violet 51 and CIRB5 anthraquinone dyes.…
The cyptomelane-type manganese oxide Octahedral Molecular Sieve (OMS-2) has been succesfully synthesized using reflux process by the reaction between KMnO4 (oxidant) and MnSO4 (reductant) in acidic conditions. The products were characterized by XRD to determine their structure, crystallinity and purity, whereas SEM is used to characterized their morphology. The XRD data indicated that the tu…
LBKURCC40 is endophytic fungi which was isolated from orange flowering dahlia tubers of plants from outside Padang, West Sumatra. Identification by Lorenita (2013), Hendris (2015) and preliminary studies showed conflicting results, indicating that the isolate was not pure. Therefore purification and reidentification of LBKURCC40 was done to establish its correct identity. This study conducted s…
Macaranga bancana (Euphorbiaceae) is known as "mahang" which is widely distributed in Indragiri Hulu, Riau Province and it is also believed to posses medicinal properties, such as anti-infection agents. This study was to isolate and characterize the secondary metabolites, and their antimicrobial activity from n-hexane and ethyl acetate extracts as well as their fractions. Extraction techniques …
Mempening (Lithocarpus bancanus) is a plant from Fagaceae family found in the Talang Mamak tribe in Kelayang District, Indragiri Hulu Regency, Riau Province. This plant is usually used by the tribe as a medicine for several diseases such as pain relief and inflammation. Some species of this genus have been reported to contain various secondary metabolites, including terpenoids, steroids and fla…
Red miana (Coleus hybridus) is one of species in genus Coleus, family Lamiaceae which is a potential source of traditional medicines. The purpose of this study is to isolate, examine biological activities, including antioxidant and toxicity from secondary metabolites of the plant. As much as 13.7 kg C. hybridus was extracted with maceration method by using methanol and separated into two fracti…
A novel bimetallic with carboxylic anchoring ligands and thiocyanate connecting ligands from the ruthenium bipyridyl complex and the tungsten carbonyl complex was synthesized. The function of anchoring ligand is to facilitate covalent bond with semi conductor surface. The black bimetallic complex solid product was soluble in polar protic solvents. The ligands and metal complexes were characteri…
Titanium dioxide is one of the most investigated materials for photoelectrochemical (PEC) water splitting. However, TiO2 has a wide band gap of approximately 3.2 eV, which limits its absorption energy to UV only, and the photoexcitation products (i.e., electron and hole) easily recombine. Developing a composite with other semiconductor materials is one of the efforts for improving the performa…
Magnetite (Fe3O4) nanoparticles is a magnetic nanomaterial that have potential properties to be applied as drug delivery. The purpose of this study was to determine the influence of time and temperature synthesis of magnetite characteristics and determine its crystal growth kinetics model with Ostwald ripening model approach. Magnetite nanoparticles synthesized from FeCl3, citrate, urea and pol…
The objectives of the research are to synthesize manganese oxide catalysts by using KMnO4 and H2C2O4 via reflux method with and without the calcination and to investigate the performance of the catalysts for the degradation of methylene blue. The products, birnessite-type octahedral layer manganese oxides have been succesfully synthesized with different reflux times. The precipitate solid pro…
Seven Flavonol derived of 2'-hydroxycalone are 2- (2-methoxyphenyl) -3-hydroxy-4H-kromen-4-on (F4), 2- (3-methoxyphenyl) -3-hydroxy-4H-kromen-4-7 on (F5), 2- (4-methoxyphenyl) -3-hydroxy-4H-kromen-4-on (F6), 2- (2,3-dimetoksifenil) -3-hydroxy-4H-kromen-4-on (F7), 2- (2,5-dimethoxyphenyl) -3-hydroxy-4H-kromen-4-on (F8), 2- (3,4-dimetoksifenil) -3-hydroxy-4H-kromen-4-on (F9) and 2- (3,4,5-dimetho…
Fusarium oxysporum is one of endophytic microbes isolated from dahlia tuber (Dahlia variabilis) which has the ability to produce secondary metabolites. The purpose of this research was to find the optimum condition of fermentation to producing secondary metabolites. Corn, potato, and sweet potato and combination of them with particle size of 80 mesh were used as carbon sources to produce second…