Chalcone is one of secondary metabolites of flavonoids that have been reported to possess biological activities such as antioxidant, antimicrobial, and anti-inflammatory. Three chalcone analogues i.e., (E)-3-(2,3-dimethoxysiphenyl)-1-(3’-hidroxyphenyl)prop-2-en-1-one (EK-1), (E)-3-(2,5-dimethoxysiphenyl)-1-(3’-hidroxyphenyl)prop-2-en-1-one (EK-2), (E)-1-(3’-hidroxyphenyl)-3-(3,4,5-trimeth…