Chronic hepatitis B is a global health problem. Chronic hepatitis B (CHB) patients are at risk of fatal liver diseases such as cirrhosis of the liver and hepatocellular carcinoma (HCC). Hepatitis B virus (HBV) is a non-cytopathic virus which means the liver damage is not caused by the virus itself but associated with the immune response against the infected hepatocytes. Interleukin-10 (IL-1…