Many studies have been found using alpha-lipoic acid (ALA) in the preventing of diabetes related chronic complications such as retinopathy, nephropathy, neuropathy, and cardiomyopathy. Langerhans island abnormality in type 2 diabetic (isletopathy) is one of the complications of type 2 diabetes. The extracellular matrix component is an important component for homeostasis, especially the communic…