ABSTRACT Papaya leaves (Carica papaya L.) contain tannins, alkaloids, flavonoids, terpenoids, saponins, and karpain alkaloids which are antiseptic, anti-inflammatory, antifungal, antibacterial and can be used as immunomodulators that can strengthen the immune system. This study aimed to obtain the best dose of fermented papaya leaf (Carica papaya L.) solution in increasing the non-specific…