Benign Prostatic Hyperplasia (BPH) is an enlargement of the prostate gland caused by epitel and stroma proliferations. The enlargement of the prostate gland can cause the increase of serum Prostate Specific Antigen (PSA). The increase of PSA which is the characteristic of organ specific is a signal of a disease in prostate. PSA can increase caused by prostate inflammation, prostate manipulationā¦