ABSTRACT Chalcone synthetic compound or natural product known as antimalaria, antioxidant, antitumor, antiinflamation and antibacterial. Biology activity ofchalcone due toα, βunsaturated system. The other hand, its strength affected by kind and pattern of thesubtituents that consist in aromatic ring.The uniqueness of chalcone got the attention of the researchers, it studied a lot as targe…