Pyridazinone is oxo-pyridazine derivative compound that has broad bioactivity, such as an analgesic, anti-inflammatory, antidiabetic, antihypertensive and anticancer. For further development of pyridazinone compounds, in this study, pyridazinone compound substituted benzenesulfonyl have been synthesized and tested their activity as antidiabetic because the target molecule has a hydrophilic …