Chalcone is the one of secondary metabolites which included into the class of flavonoids that are known to have biological activities. Chalcone can be used as an intermediate for synthesizing heterocyclic compounds, such as flavones, flavanols, flavanones and others that also have biological activities. Two chalcone analogues i.e. (E)-3-(2,5-dimetoksifenil)-1-(2’-metoksifenil)prop-2-en-1-on (…