Depression is a mental disorder involving mood swings that can be treated using antidepressants. Areca nut extract has potential as an antidepressant drug and has been tested in vivo and in silico. Test results using the Forced Swim Test (FST) method for simultaneous test animals showed that n-hexane extract of old areca nut seeds (ENHPT) 50 mg/kg was the best dose as an antidepressant drug and…