Mahkota Dewa (Phaleria macrocarpa (Scheff) Boerl.) is one type of plant that is used as an ingredient in traditional medicine. The secondary metabolite content of Mahkota Dewa fruit can prevent free radicals. The spleen is an organ that plays a role in the body's immune system. Mahkota Dewa fruit contains antioxidant compounds that can improve the immune system. The purpose of the study was the…