The crude polar extract of mangosteen pericarp not only has a relatively high antioxidant activity (55±4) μg/mL, but also has high cytotoxicity (16±0.5 μg/mL). This high cytotoxicity presumably is caused by the presence of complex cytotoxic compounds from the mangosteen pericarp. To obtain a non-toxic extract preparation with high antioxidant activity, crude polar 50% ethanol extracts of ma…