Pyrazole is a 5-ring heterocyclic compound which consist of 3 carbon atoms and 2 neighboring nitrogen atoms. Pyrazoline compound, namely 5-(4-chlorophenyl)-3-(naphthalene-2-il)-1-phenyl-4,5-dihydro-1H-pyrazole (PF CN2-2F) was synthesized using one-pot reaction method of a mixture of 2-acetyl-naphthalene compounds, 4-chloro-benzaldehyde and phenylhydrazine this reaction was catalyzed by NaOH wit…
Rukam is one of the species of Flacourtiaceae which is widely distributed in Sumatra and used as anti-diarrhea and anti-inflamatory ethnomedicine. Several species of this genus were reported to have antioxidant and cytotoxic activity. Phytochemical analysis showed that the leaf of rukam contained of flavonoids, saponins, fenolic, terpenoids and steroids. This study was aimed to isolate secondar…
Cryptomelane is a hollow type manganese oxide mineral that has a tunnel structure of 2x2. The mineral cryptomelane can be used as an adsorbent and catalyst for the degradation of organic compound wastes. The purpose of this study was to synthesize cryptomelane type manganese oxide by sol-gel method using KMnO4 and C6H8O7. The products were then treated with an acid (acetic acid) and base (KOH) …
The stem bark of Litsea glutinosa (medang lendir) from the Lauraceae family has been used as mosquito repellent by indigeneous community in Kampar Kiri Hulu Sub-District, Riau Province. This study was aimed to isolate a secondary metabolite from ethyl acetate extract of the stem bark. The ethyl acetate extract was separated by VLC to give 11 fractions. Isolation was done at fraction of 3 and is…
Plants of the Litsea genus are known to have anticancer bioactivity, anti-HIV and as cytotoxicity agents. Medang lendir (Litsea glutinosa) is a species of the Lauraceae family which is commonly found in tropical and sub-tropical regions. The local people uses the bark to repel mosquitoes by burning its stem barks. Phytochemical tests to this barks showed the presence of secondary metabolites of…
Coleus hybridus, also known as miana merah, is a traditional medicinal plant of the genus Coleus from the family Lamiaceae or Labiatae. This plant possess various bioactivities such as antioxidants, antibacterial, antivirus and anti-inflamation. The purpose of this research was to isolate and toxicity assay secondary metabolites from dichloromethane (DCM) extract of the aerial parts of this pl…
Coronavirus disease or Covid-19 is a disease caused by a new type of corona virus, SARS-CoV-2. This disease first appeared in Wuhan, China and has now become a pandemic in the world. This study aims to find compounds that have the potential to inhibit the main protease enzyme (Mpro) of the corona virus (PBD ID: 6LU7 and 2GTB) through a computational molecular docking modeling approach to terpen…
Flacourtia rukam is one of the species of Flacourtiaceae which is widely spread in Indonesia. This plant commonly used as traditional medicine by various tribes in Indonesia. Several species of this genus are reported ho have antimalarial, antioxidant, antibacterial, and anti-inflammatory. This study is to isolate secondary metabolite and determine the toxicity of fraction. Isolation techniques…
Mempening (L. bancanus) is a species of the family Fagaceae. It can be found on hillsides and sandy mountains to clay, but can also be found in peat swamp forests. The purpose of this study was to isolate and test the toxicity of secondary metabolites from the n-hexane fraction obtained from the leaves of the L. bancanus plant. Isolation was carried out by maceration method for 72 hours. A pure…
Kelakai (S. palustris) is an epiphytic plant that is widely used as a medicinal plant. This study aims to isolate the antioxidant active compounds contained in this species. Isolation of compounds was carried out by maceration method by using methanol and then partitioned with n-hexane to obtain n-hexane extract. The n-hexane extract was separated by using Vacuum Liquid Chromatography (VLC), fo…
Hydrazone is a versatile organic compound that has a basic structure (R1R2C=N-NR3R4). The active group of the hydrazone compound is azomethine (-NHN=CH-), which makes this compound the most important in the development of new medicines. In this research, the synthesis of the compound hydrazine 1,2-bis(naphthalene-1-ilmethylene)hydrazine (IHA-ND1) obtained from the condensation reaction bet…
Magnesium oxide is a basic metal oxide which has catalytic activity in the triglyceride transesterification reaction, Michael's addition and Knoevenagel condensation. Commercial magnesium oxide has a surface area less than 20 m2/g, thus ineffective in catalytic reaction. Coprecipitation is a synthesis method of inorganic compounds with the simple process and produces the small and uniform parti…
Vittaria elongata is one of fern that comes from the Pteridaceae family. It is commonly found on palm tree trunks, but not extensively studied. This investigation was intended to isolate V. elongata secondary metabolitefrom hexane extract. The plant was extracted by using macereation in methanol. The extract was then partinioned with n-hexane, dicloromethana, ethyl acetate and water. Furthermo…
Stenochlaena palustris is a Stenochlaena species that is often found in marshes, palms and often forms thick bushes which stretch all over the world. Some of these species were used as antioxidants and antibacterial activities. This study aimed to isolate the secondary metabolites of n-hexane extract contained in S. palustris and to determine the toxicity activity of the extracts, fractions, an…
ABSTRACT Papaya leaves (Carica papaya L) have long been used by Indonesians for food and medicine. Papaya leaves have been reported to have several benefits, namely antitumor, dengue fever, and have antioxidant properties. The antioxidants in papaya leaves can be obtained from the flavonoid compounds contained in the leaves. This study aims to determine the levels of flavonoids extracted f…
ABSTRACT Generally, durian seeds are waste in the surrounding environment. The high starch content in durian seeds has the potential to be processed into flour. At the flour manufacturing stage, the drying process affects the characteristics of the flour produced. This study aims to determine the effect of drying temperature variations on the characteristics of durian seed flour in the for…
ABSTRACT Gelatin was a natural product that was obtained from hydrolysis of collagen. Gelatin comes from beef, fish, pork, chicken feet, etc. This study aimed to extract gelatin from chicken feet, know the effect of immersion time in HCl 5% 250 mL solution (3,5,7 days) and chicken feet texture (smooth and coarse) on yield and some physical properties of gelatin products from chicken feet. …
ABSTRACT Sodium Silicate is a raw material that is widely used as a filler in the detergent, soap and toothpaste industries. Sodium silicate can be synthesized from silica (SiO2), which can be obtained through the extraction process from silica-containing materials such as sand, clear glass waste or straw. In the synthesis of sodium silicate, silica is reacted with NaOH solution at a relat…
ABSTRACT Silica sand is a material that is commonly found in Indonesia. However, the silica sand found is not in a pure state, so it needs to be refined. One method for purifying silica from its impurities is the acid leaching method. Acid leaching or liquid solid extraction method is a contact between the solid phase and the liquid phase (acid) where the solute diffuses from the solid pha…
ABSTRACT Silica sand is a material that is commonly found in Indonesia. However, the silica sand found is not in a pure state, so it needs to be refined. One method for purifying silica from its impurities is the acid leaching method. Acid leaching or liquid solid extraction method is a contact between the solid phase and the liquid phase (acid) where the solute diffuses from the solid pha…