Chalcone is one of secondary metabolites that has been reported to possess biological activities such as antimicrobial, antitumor, antioxidant, anti-inflammatory, antimalarial, and anticancer. Chalcone can be used as an intermediate for synthesizing heterocyclic compounds such as flavones, flavanols, flavanones, etc. Chalcone has been synthesized using (E)-1-(4'-hydroxyphenyl)-3-(3-methoxypheny…